【摘要】 目的合成非布司他。方法以2-(3-甲酰基-4-羟基苯基)-4-甲基-噻唑-5-甲酸乙酯为起始原料,经醚化、氰化、水解制得目标化合物。结果目标化合物经核磁共振氢谱、质谱、红外光谱及元素分析等确证其化学结构,总收率46.1%。结论本工艺反应条件温和,成本较低,环境污染小,产品纯度高,质量容易控制。更多还原

【Abstract】 Objective To synthesize febuxostat.Methods Starting from ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate,febuxostat was prepared via a series of steps including etherification,cyanide,hydrolysis.Results The structure of febuxostat was verified by 1HNMR,MS,IR and element analysis.The total yield of febuxostat was 46.1%.Conclusion In the synthesis of febuxostat,reaction condition is temperate,the cost is low,the environmental pollution is small,the product purity is high,and the product quality is easy to control.更多还原